Sofosbuvir Selects for Drug-Resistant Amino Acid Variants in the Zika Virus RNA-Dependent RNA-Polymerase Complex In Vitro

The nucleotide analog sofosbuvir, licensed for the treatment of hepatitis C, recently revealed activity against the Zika virus (ZIKV) in vitro and in animal models. However, the ZIKV genetic barrier to sofosbuvir has not yet been characterized. In this study, in vitro selection experiments were perf...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Boccuto, Adele, Dragoni, Filippo, Picarazzi, Francesca, Lai, Alessia, Della Ventura, Carla, Veo, Carla, Giammarino, Federica, Saladini, Francesco, Zehender, Gianguglielmo, Zazzi, Maurizio, Mori, Mattia, Vicenti, Ilaria
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7962015/
https://ncbi.nlm.nih.gov/pubmed/33800884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22052670
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