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Haplotype-resolved de novo assembly using phased assembly graphs with hifiasm
Haplotype-resolved de novo assembly is the ultimate solution to the study of sequence variations in a genome. However, existing algorithms either collapse heterozygous alleles into one consensus copy or fail to cleanly separate the haplotypes to produce high-quality phased assemblies. Here we descri...
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| Publicado no: | Nat Methods |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7961889/ https://ncbi.nlm.nih.gov/pubmed/33526886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-020-01056-5 |
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