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Haplotype-resolved de novo assembly using phased assembly graphs with hifiasm

Haplotype-resolved de novo assembly is the ultimate solution to the study of sequence variations in a genome. However, existing algorithms either collapse heterozygous alleles into one consensus copy or fail to cleanly separate the haplotypes to produce high-quality phased assemblies. Here we descri...

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Publié dans:Nat Methods
Auteurs principaux: Cheng, Haoyu, Concepcion, Gregory T, Feng, Xiaowen, Zhang, Haowen, Li, Heng
Format: Artigo
Langue:Inglês
Publié: 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7961889/
https://ncbi.nlm.nih.gov/pubmed/33526886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-020-01056-5
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