Discovery of Dihydropyrrolo[1,2-a]pyrazin-3(4H)-one-Based Second-Generation GluN2C- and GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N-Methyl-d-Aspartate (NMDA) Receptor

The N-methyl-d-aspartate receptor (NMDAR) is an ion channel that mediates the slow, Ca(2+)-permeable component of glutamatergic synaptic transmission in the central nervous system (CNS). NMDARs are known to play a significant role in basic neurological functions, and their dysfunction has been impli...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Epplin, Matthew P., Mohan, Ayush, Harris, Lynnea D., Zhu, Zongjian, Strong, Katie L., Bacsa, John, Le, Phuong, Menaldino, David S., Traynelis, Stephen F., Liotta, Dennis C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7961853/
https://ncbi.nlm.nih.gov/pubmed/32538088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01733
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