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Transcriptional profiling of the response to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine revealed activation of the eIF2α/ATF4 integrated stress response in two in vitro placental models

Trichloroethylene (TCE) is an industrial solvent and widespread environmental contaminant. Although TCE exposure is prevalent, epidemiological studies of TCE exposure associations with adverse birth outcomes are inconclusive. Prior studies show that the TCE metabolite S-(1,2-dichlorovinyl)-l-cystein...

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Dettagli Bibliografici
Pubblicato in:Arch Toxicol
Autori principali: Elkin, Elana R., Bakulski, Kelly M., Colacino, Justin A., Bridges, Dave, Kilburn, Brian A., Armant, D. Randall, Loch-Caruso, Rita
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7961173/
https://ncbi.nlm.nih.gov/pubmed/33725128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-021-03011-5
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