Transcriptional profiling of the response to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine revealed activation of the eIF2α/ATF4 integrated stress response in two in vitro placental models

Trichloroethylene (TCE) is an industrial solvent and widespread environmental contaminant. Although TCE exposure is prevalent, epidemiological studies of TCE exposure associations with adverse birth outcomes are inconclusive. Prior studies show that the TCE metabolite S-(1,2-dichlorovinyl)-l-cystein...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Elkin, Elana R., Bakulski, Kelly M., Colacino, Justin A., Bridges, Dave, Kilburn, Brian A., Armant, D. Randall, Loch-Caruso, Rita
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2021
Assuntos:
Toxicogenomics and Omics Technologies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7961173/
https://ncbi.nlm.nih.gov/pubmed/33725128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-021-03011-5
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