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Transcriptional profiling of the response to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine revealed activation of the eIF2α/ATF4 integrated stress response in two in vitro placental models

Trichloroethylene (TCE) is an industrial solvent and widespread environmental contaminant. Although TCE exposure is prevalent, epidemiological studies of TCE exposure associations with adverse birth outcomes are inconclusive. Prior studies show that the TCE metabolite S-(1,2-dichlorovinyl)-l-cystein...

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Vydáno v:Arch Toxicol
Hlavní autoři: Elkin, Elana R., Bakulski, Kelly M., Colacino, Justin A., Bridges, Dave, Kilburn, Brian A., Armant, D. Randall, Loch-Caruso, Rita
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7961173/
https://ncbi.nlm.nih.gov/pubmed/33725128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-021-03011-5
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