Cyclin-dependent kinase inhibitors exert distinct effects on patient-derived 2D and 3D glioblastoma cell culture models

Current therapeutic approaches have met limited clinical success for glioblastoma multiforme (GBM). Since GBM harbors genomic alterations in cyclin-dependent kinases (CDKs), targeting these structures with specific inhibitors (CDKis) is promising. Here, we describe the antitumoral potential of selec...

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Vydáno v:Cell Death Discov
Hlavní autoři: Riess, Christin, Koczan, Dirk, Schneider, Björn, Linke, Charlotte, del Moral, Katharina, Classen, Carl Friedrich, Maletzki, Claudia
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7961149/
https://ncbi.nlm.nih.gov/pubmed/33723248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-021-00423-1
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