HSF1 inhibition attenuates HIV-1 latency reversal mediated by several candidate LRAs In Vitro and Ex Vivo

HIV-1 latency is a major barrier to cure. Identification of small molecules that destabilize latency and allow immune clearance of infected cells could lead to treatment-free remission. In vitro models of HIV-1 latency involving cell lines or primary cells have been developed for characterization of...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Timmons, Andrew, Fray, Emily, Kumar, Mithra, Wu, Fengting, Dai, Weiwei, Bullen, Cynthia Korin, Kim, Peggy, Hetzel, Carrie, Yang, Chao, Beg, Subul, Lai, Jun, Pomerantz, Joel L., Yukl, Steven A., Siliciano, Janet D., Siliciano, Robert F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959657/
https://ncbi.nlm.nih.gov/pubmed/32571938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1916290117
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