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Experimentally determined strengths of favorable and unfavorable interactions of amide atoms involved in protein self-assembly in water

Folding and other protein self-assembly processes are driven by favorable interactions between O, N, and C unified atoms of the polypeptide backbone and side chains. These processes are perturbed by solutes that interact with these atoms differently than water does. Amide NH···O=C hydrogen bonding a...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Cheng, Xian, Shkel, Irina A., O’Connor, Kevin, Record, M. Thomas
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959557/
https://ncbi.nlm.nih.gov/pubmed/33087561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2012481117
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