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Evaluation of Glycolytic Response to Multiple Classes of Anti-glioblastoma Drugs by Noninvasive Measurement of Pyruvate Kinase M2 Using [(18)F]DASA-23
PURPOSE: Pyruvate kinase M2 (PKM2) catalyzes the final step in glycolysis, the key process of tumor metabolism. PKM2 is found in high levels in glioblastoma (GBM) cells with marginal expression within healthy brain tissue, rendering it a key biomarker of GBM metabolic reprogramming. Our group has re...
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| Pubblicato in: | Mol Imaging Biol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7959514/ https://ncbi.nlm.nih.gov/pubmed/30989436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11307-019-01353-2 |
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