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CBMT-07. EVALUATION OF GLYCOLYTIC RESPONSE TO SEVEN CLASSES OF ANTI-GLIOBLASTOMA DRUGS BY NON-INVASIVE MEASUREMENT OF PYRUVATE KINASE M2
INTRODUCTION: Pyruvate kinase M2 (PKM2) catalyzes the final and rate-limiting step in glycolysis, a key step in tumor growth and metabolism. PKM2 is preferentially expressed by glioblastoma (GBM) cells with minimal expression in the healthy brain, making it an important marker of cancer glycolytic r...
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| Publié dans: | Neuro Oncol |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6216947/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.126 |
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