BIMG-13. A NOVEL RADIOPHARMACEUTICAL ([(18)F]DASA-23) TO MONITOR PYRUVATE KINASE M2 INDUCED GLYCOLYTIC REPROGRAMMING IN GLIOBLASTOMA

BACKGROUND: Pyruvate kinase M2 (PKM2) catalyzes the final step in glycolysis, a key process of cancer metabolism. PKM2 is preferentially expressed by glioblastoma (GBM) cells with minimal expression in healthy brain, making it an important biomarker of cancer glycolytic re-programming. We describe t...

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Publicat a:Neurooncol Adv
Autors principals: Beinat, Corinne, Patel, Chirag, Haywood, Tom, Murty, Surya, Naya, Lewis, Hayden-Gephart, Melanie, Khalighi, Mehdi, Massoud, Tarik, Iagaru, Andrei, Davidzon, Guido, Thomas, Reena, Nagpal, Seema, Recht, Lawrence, Gambhir, Sanjiv
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2021
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Supplement Abstracts
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7992247/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdab024.012
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