MNK2 governs the macrophage antiinflammatory phenotype

Tumor-associated macrophages (TAMs) continuously fine tune their immune modulatory properties, but how gene expression programs coordinate this immune cell plasticity is largely unknown. Selective mRNA translation, controlled by MNK1/MNK2 and mTOR pathways impinging on eIF4E, facilitates reshaping o...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bartish, Margarita, Tong, Dongmei, Pan, Yangxun, Wallerius, Majken, Liu, Hui, Ristau, Johannes, de Souza Ferreira, Sabrina, Wallmann, Tatjana, van Hoef, Vincent, Masvidal, Laia, Kerzel, Thomas, Joly, Anne-Laure, Goncalves, Christophe, Preston, Samuel E. J., Ebrahimian, Talin, Seitz, Christina, Bergh, Jonas, Pietras, Kristian, Lehoux, Stephanie, Naldini, Luigi, Andersson, John, Squadrito, Mario Leonardo, del Rincón, Sonia V., Larsson, Ola, Rolny, Charlotte
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959504/
https://ncbi.nlm.nih.gov/pubmed/33077599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920377117
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