B3GALT5 knockout alters gycosphingolipid profile and facilitates transition to human naïve pluripotency

Conversion of human pluripotent stem cells from primed to naïve state is accompanied by altered transcriptome and methylome, but glycosphingolipid (GSL) profiles in naïve human embryonic stem cells (hESCs) have not been systematically characterized. Here we showed a switch from globo-(SSEA-3, SSEA-4...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Lin, Ruey-Jen, Kuo, Ming-Wei, Yang, Bei-Chia, Tsai, Hsiu-Hui, Chen, Kowa, Huang, Jing-Rong, Lee, Yun-Shien, Yu, Alice L., Yu, John
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959494/
https://ncbi.nlm.nih.gov/pubmed/33087559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003155117
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