B3GALT5 knockout alters gycosphingolipid profile and facilitates transition to human naïve pluripotency

Conversion of human pluripotent stem cells from primed to naïve state is accompanied by altered transcriptome and methylome, but glycosphingolipid (GSL) profiles in naïve human embryonic stem cells (hESCs) have not been systematically characterized. Here we showed a switch from globo-(SSEA-3, SSEA-4...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Lin, Ruey-Jen, Kuo, Ming-Wei, Yang, Bei-Chia, Tsai, Hsiu-Hui, Chen, Kowa, Huang, Jing-Rong, Lee, Yun-Shien, Yu, Alice L., Yu, John
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7959494/
https://ncbi.nlm.nih.gov/pubmed/33087559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003155117
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