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Discovery and engineering of colchicine alkaloid biosynthesis

Few complete pathways are established for the biosynthesis of medicinal compounds from plants. Accordingly, many plant-derived therapeutics are isolated directly from medicinal plants or plant cell culture.(1) A lead example is colchicine, an FDA-approved treatment for inflammatory disorders that is...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Nett, Ryan S., Lau, Warren, Sattely, Elizabeth S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958869/
https://ncbi.nlm.nih.gov/pubmed/32699417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2546-8
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