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Impact of cholesterol concentration and lipid phase on structure and fluctuation of amyloid precursor protein

Elevated levels of cellular cholesterol have been identified as one factor contributing to the onset of Alzheimer’s Disease (AD). Specific interaction between cholesterol and the Amyloid Precursor Protein (APP), investigated via NMR experiments and computational stusdies, has been proposed to play a...

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Detalhes bibliográficos
Publicado no:J Phys Chem B
Main Authors: Pantelopulos, George A., Panahi, Afra, Straub, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958706/
https://ncbi.nlm.nih.gov/pubmed/33135883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.0c07615
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