Architecturally complex O-glycopeptidases are customized for mucin recognition and hydrolysis

A challenge faced by peptidases is the recognition of highly diverse substrates. A feature of some peptidase families is the capacity to specifically use post-translationally added glycans present on their protein substrates as a recognition determinant. This is ultimately critical to enabling pepti...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pluvinage, Benjamin, Ficko-Blean, Elizabeth, Noach, Ilit, Stuart, Christopher, Thompson, Nicole, McClure, Hayden, Buenbrazo, Nakita, Wakarchuk, Warren, Boraston, Alisdair B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958395/
https://ncbi.nlm.nih.gov/pubmed/33658366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019220118
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