Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone

Adjunctive treatment with antiinflammatory corticosteroids like dexamethasone increases survival in tuberculosis meningitis. Dexamethasone responsiveness associates with a C/T variant in Leukotriene A4 Hydrolase (LTA4H), which regulates expression of the proinflammatory mediator leukotriene B(4) (LT...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Whitworth, Laura J., Troll, Rajan, Pagán, Antonio J., Roca, Francisco J., Edelstein, Paul H., Troll, Mark, Tobin, David M., Phu, Nguyen Hoan, Bang, Nguyen Duc, Thwaites, Guy E., Thuong, Nguyen Thuy Thuong, Sewell, Roger F., Ramakrishnan, Lalita
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958233/
https://ncbi.nlm.nih.gov/pubmed/33658385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024852118
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