Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone

Adjunctive treatment with antiinflammatory corticosteroids like dexamethasone increases survival in tuberculosis meningitis. Dexamethasone responsiveness associates with a C/T variant in Leukotriene A4 Hydrolase (LTA4H), which regulates expression of the proinflammatory mediator leukotriene B(4) (LT...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Whitworth, Laura J., Troll, Rajan, Pagán, Antonio J., Roca, Francisco J., Edelstein, Paul H., Troll, Mark, Tobin, David M., Phu, Nguyen Hoan, Bang, Nguyen Duc, Thwaites, Guy E., Thuong, Nguyen Thuy Thuong, Sewell, Roger F., Ramakrishnan, Lalita
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958233/
https://ncbi.nlm.nih.gov/pubmed/33658385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024852118
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