Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone

Adjunctive treatment with antiinflammatory corticosteroids like dexamethasone increases survival in tuberculosis meningitis. Dexamethasone responsiveness associates with a C/T variant in Leukotriene A4 Hydrolase (LTA4H), which regulates expression of the proinflammatory mediator leukotriene B(4) (LT...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Whitworth, Laura J., Troll, Rajan, Pagán, Antonio J., Roca, Francisco J., Edelstein, Paul H., Troll, Mark, Tobin, David M., Phu, Nguyen Hoan, Bang, Nguyen Duc, Thwaites, Guy E., Thuong, Nguyen Thuy Thuong, Sewell, Roger F., Ramakrishnan, Lalita
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2021
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958233/
https://ncbi.nlm.nih.gov/pubmed/33658385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024852118
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