Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone

Adjunctive treatment with antiinflammatory corticosteroids like dexamethasone increases survival in tuberculosis meningitis. Dexamethasone responsiveness associates with a C/T variant in Leukotriene A4 Hydrolase (LTA4H), which regulates expression of the proinflammatory mediator leukotriene B(4) (LT...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Whitworth, Laura J., Troll, Rajan, Pagán, Antonio J., Roca, Francisco J., Edelstein, Paul H., Troll, Mark, Tobin, David M., Phu, Nguyen Hoan, Bang, Nguyen Duc, Thwaites, Guy E., Thuong, Nguyen Thuy Thuong, Sewell, Roger F., Ramakrishnan, Lalita
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2021
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958233/
https://ncbi.nlm.nih.gov/pubmed/33658385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024852118
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