Discovery of Imidazopyridines as Potent Inhibitors of Indoleamine 2,3-Dioxygenase 1 for Cancer Immunotherapy

[Image: see text] Indoleamine 2,3-dioxygenase 1 (IDO1) has been identified as a target for small-molecule immunotherapy for the treatment of a variety of cancers including renal cell carcinoma and metastatic melanoma. This work focuses on the identification of IDO1 inhibitors containing replacements...

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Publié dans:ACS Med Chem Lett
Auteurs principaux: Zhang, Liping, Cherney, Emily C., Zhu, Xiao, Lin, Tai-an, Gullo-Brown, Johnni, Maley, Derrick, Johnston-Allegretto, Kathy, Kopcho, Lisa, Fereshteh, Mark, Huang, Christine, Li, Xin, Traeger, Sarah C., Dhar, Gopal, Anandam, Aravind, Mahankali, Sandeep, Padmanabhan, Shweta, Rajanna, Prabhakar, Murali, Venkata, Mariappan, Thanga, Borzilleri, Robert, Vite, Gregory, Hunt, John T., Balog, Aaron
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2021
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958151/
https://ncbi.nlm.nih.gov/pubmed/33738077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00014
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