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Structure-based Discovery of Cell-Potent Peptidomimetic Inhibitors for Protein N-Terminal Methyltransferase 1

[Image: see text] Protein N-terminal methyltransferases (NTMTs) catalyze the methylation of the α-N-terminal amines of proteins starting with an X–P–K/R motif. NTMT1 has been implicated in various cancers and in aging, implying its role as a potential therapeutic target. Through structural modificat...

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Publicat a:ACS Med Chem Lett
Autors principals: Chen, Dongxing, Dong, Guangping, Deng, Youchao, Noinaj, Nicholas, Huang, Rong
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2021
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7958150/
https://ncbi.nlm.nih.gov/pubmed/33738076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00012
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