Rabdosianone I, a Bitter Diterpene from an Oriental Herb, Suppresses Thymidylate Synthase Expression by Directly Binding to ANT2 and PHB2

SIMPLE SUMMARY: In the present study, we found the novel pleiotropic regulation of the oncogene product thymidylate synthase (TS) by a chemical biology approach to identify rabdosianone I-binding proteins. Rabdosianone I, which is extracted from a traditional Asian herb Isodon japonicus Hara for lon...

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Détails bibliographiques
Publié dans:Cancers (Basel)
Auteurs principaux: Watanabe, Motoki, Yamada, Yasumasa, Kurumida, Yoichi, Kameda, Tomoshi, Sukeno, Mamiko, Iizuka-Ohashi, Mahiro, Sowa, Yoshihiro, Iizumi, Yosuke, Takakura, Hideki, Miyamoto, Shingo, Sakai, Toshiyuki, Mutoh, Michihiro
Format: Artigo
Langue:Inglês
Publié: MDPI 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7956614/
https://ncbi.nlm.nih.gov/pubmed/33652782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13050982
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