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HIF-Prolyl Hydroxylase Domain Proteins (PHDs) in Cancer—Potential Targets for Anti-Tumor Therapy?

SIMPLE SUMMARY: In solid tumors, proliferation of cancer cells typically outpaces the growth of functional vessels. The net result is often an obstructed blood circulation and areas of deprived oxygen (hypoxia). To overcome this acute stress, hypoxia inducible factors (HIFs) stimulate the expression...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancers (Basel)
Prif Awduron: Gaete, Diana, Rodriguez, Diego, Watts, Deepika, Sormendi, Sundary, Chavakis, Triantafyllos, Wielockx, Ben
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7956578/
https://ncbi.nlm.nih.gov/pubmed/33673417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13050988
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