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HIF-Prolyl Hydroxylase Domain Proteins (PHDs) in Cancer—Potential Targets for Anti-Tumor Therapy?

SIMPLE SUMMARY: In solid tumors, proliferation of cancer cells typically outpaces the growth of functional vessels. The net result is often an obstructed blood circulation and areas of deprived oxygen (hypoxia). To overcome this acute stress, hypoxia inducible factors (HIFs) stimulate the expression...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Gaete, Diana, Rodriguez, Diego, Watts, Deepika, Sormendi, Sundary, Chavakis, Triantafyllos, Wielockx, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7956578/
https://ncbi.nlm.nih.gov/pubmed/33673417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13050988
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