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Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1
Rac1 is a major regulator of actin dynamics, with GTP-bound Rac1 promoting actin assembly via the Scar/WAVE complex. CYRI competes with Scar/WAVE for interaction with Rac1 in a feedback loop regulating actin dynamics. Here, we reveal the nature of the CYRI-Rac1 interaction, through crystal structure...
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| Опубликовано в: : | Structure |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cell Press
2021
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7955166/ https://ncbi.nlm.nih.gov/pubmed/33217330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.11.003 |
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