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Tetrahydroindazole inhibitors of CDK2/cyclin complexes
Over 50 tetrahydroindazoles were synthesized after 7-bromo-3,6,6-trimethyl-1-(pyridin-2-yl)-5,6,7,7a-tetrahydro-1H-indazol-4(3aH)-one (3) was identified as a hit compound in a high throughput screen for inhibition of CDK2 in complex with cyclin A. The activity of the most promising analogues was eva...
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| Publié dans: | Eur J Med Chem |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7954990/ https://ncbi.nlm.nih.gov/pubmed/33550184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2021.113232 |
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