Decoding the Protein Composition of Whole Nucleosomes with Nuc-MS

Current proteomics approaches disassemble and digest nucleosome particles, blurring the readout of the “histone code”. To preserve nucleosome-level information, we developed Nuc-MS which displays the landscape of histone variants and their PTMs in a single mass spectrum. Combined with immunoprecipit...

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Vydáno v:Nat Methods
Hlavní autoři: Schachner, Luis F., Jooβ, Kevin, Morgan, Marc A., Piunti, Andrea, Meiners, Matthew J., Kafader, Jared O., Lee, Alexander S., Iwanaszko, Marta, Cheek, Marcus A., Burg, Jonathan M., Howard, Sarah A., Keogh, Michael-Christopher, Shilatifard, Ali, Kelleher, Neil L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954958/
https://ncbi.nlm.nih.gov/pubmed/33589837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-020-01052-9
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