Separation and Characterization of Endogenous Nucleosomes by Native Capillary Zone Electrophoresis–Top-Down Mass Spectrometry

We report a novel platform [native capillary zone electrophoresis–top-down mass spectrometry (nCZE–TDMS)] for the separation and characterization of whole nucleosomes, their histone subunits, and post-translational modifications (PTMs). As the repeating unit of chromatin, mononucleosomes (Nucs) are...

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Publicado no:Anal Chem
Main Authors: Jooß, Kevin, Schachner, Luis F., Watson, Rachel, Gillespie, Zachary B., Howard, Sarah A., Cheek, Marcus A., Meiners, Matthew J., Sobh, Amin, Licht, Jonathan D., Keogh, Michael-Christopher, Kelleher, Neil L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8040852/
https://ncbi.nlm.nih.gov/pubmed/33749242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.0c04975
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