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Multi-stage adaptive enrichment trial design with subgroup estimation
We consider the problem of estimating the best subgroup and testing for treatment effect in a clinical trial. We define the best subgroup as the subgroup that maximizes a utility function that reflects the trade-off between the subgroup size and the treatment effect. For moderate effect sizes and sa...
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| Vydáno v: | J Biopharm Stat |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7954857/ https://ncbi.nlm.nih.gov/pubmed/33073685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2020.1832109 |
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