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Fully phased human genome assembly without parental data using single-cell strand sequencing and long reads
Human genomes are typically assembled as consensus sequences that lack information on parental haplotypes. Here we describe a reference-free workflow for diploid de novo genome assembly that combines the chromosome-wide phasing and scaffolding capabilities of single-cell strand sequencing(1,2) with...
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| Foilsithe in: | Nat Biotechnol |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Nature Publishing Group US
2020
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7954704/ https://ncbi.nlm.nih.gov/pubmed/33288906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-020-0719-5 |
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