An abundant biliary metabolite derived from dietary omega-3 polyunsaturated fatty acids regulates triglycerides

Omega-3 fatty acids from fish oil reduce triglyceride levels in mammals, yet the mechanisms underlying this effect have not been fully clarified, despite the clinical use of omega-3 ethyl esters to treat severe hypertriglyceridemia and reduce cardiovascular disease risk in humans. Here, we identifie...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Grevengoed, Trisha J., Trammell, Samuel A.J., Svenningsen, Jens S., Makarov, Mikhail V., Nielsen, Thomas Svava, Jacobsen, Jens Christian Brings, Treebak, Jonas T., Calder, Philip C., Migaud, Marie E., Cravatt, Benjamin F., Gillum, Matthew P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954602/
https://ncbi.nlm.nih.gov/pubmed/33507883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI143861
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