A Covalent p97/VCP ATPase Inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells

Small-molecule inhibitors of p97 are useful tools to study p97 function. Human p97 is an important AAA ATPase due to its diverse cellular functions and implication in mediating the turnover of proteins involved in tumorigenesis and virus infections. Multiple p97 inhibitors identified from previous h...

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Bibliografiset tiedot
Julkaisussa:Eur J Med Chem
Päätekijät: Zhang, Gang, Li, Shan, Wang, Feng, Jones, Amanda C., Goldberg, Alexander F. G., Lin, Benjamin, Virgil, Scott, Stoltz, Brian M., Deshaies, Raymond J., Chou, Tsui-Fen
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2021
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7954469/
https://ncbi.nlm.nih.gov/pubmed/33476933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.113148
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