Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE

Variations in many genes linked to sporadic Alzheimer’s disease (AD) show abundant expression in microglia, but relationships among these genes remain largely elusive. Here, we establish isogenic human ESC–derived microglia-like cell lines (hMGLs) harboring AD variants in CD33, INPP5D, SORL1, and TR...

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Dades bibliogràfiques
Publicat a:J Exp Med
Autors principals: Liu, Tongfei, Zhu, Bing, Liu, Yan, Zhang, Xiaoming, Yin, Jun, Li, Xiaoguang, Jiang, LuLin, Hodges, Andrew P., Rosenthal, Sara Brin, Zhou, Lisa, Yancey, Joel, McQuade, Amanda, Blurton-Jones, Mathew, Tanzi, Rudolph E., Huang, Timothy Y., Xu, Huaxi
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2020
Matèries:
Technical Advances and Resources
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953740/
https://ncbi.nlm.nih.gov/pubmed/32941599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200474
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