Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE

Variations in many genes linked to sporadic Alzheimer’s disease (AD) show abundant expression in microglia, but relationships among these genes remain largely elusive. Here, we establish isogenic human ESC–derived microglia-like cell lines (hMGLs) harboring AD variants in CD33, INPP5D, SORL1, and TR...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Liu, Tongfei, Zhu, Bing, Liu, Yan, Zhang, Xiaoming, Yin, Jun, Li, Xiaoguang, Jiang, LuLin, Hodges, Andrew P., Rosenthal, Sara Brin, Zhou, Lisa, Yancey, Joel, McQuade, Amanda, Blurton-Jones, Mathew, Tanzi, Rudolph E., Huang, Timothy Y., Xu, Huaxi
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
Assuntos:
Technical Advances and Resources
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953740/
https://ncbi.nlm.nih.gov/pubmed/32941599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200474
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