Immunotherapy during the acute SHIV infection of macaques confers long-term suppression of viremia

We report that combination bNAb immunotherapy initiated on day 3 post-infection (PI) maintained durable CD8(+) T cell–mediated suppression of SHIV(AD8) viremia and preinoculation levels of CD4(+) T cells in 9 of 13 treated monkeys during nearly 6 yr of observation, as assessed by successive CD8(+) T...

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Udgivet i:J Exp Med
Main Authors: Nishimura, Yoshiaki, Donau, Olivia K., Dias, Joana, Ferrando-Martinez, Sara, Jesteadt, Eric, Sadjadpour, Reza, Gautam, Rajeev, Buckler-White, Alicia, Geleziunas, Romas, Koup, Richard A., Nussenzweig, Michel C., Martin, Malcolm A.
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953630/
https://ncbi.nlm.nih.gov/pubmed/32966579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201214
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