A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans

Jagunal homolog 1 (JAGN1) has been identified as a critical regulator of neutrophil biology in mutant mice and rare-disease patients carrying JAGN1 mutations. Here, we report that Jagn1 deficiency results in alterations in the endoplasmic reticulum (ER) of antibody-producing cells as well as decreas...

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Publicado no:J Exp Med
Main Authors: Hagelkruys, Astrid, Wirnsberger, Gerald, Stadlmann, Johannes, Wöhner, Miriam, Horrer, Marion, Vilagos, Bojan, Jonsson, Gustav, Kogler, Melanie, Tortola, Luigi, Novatchkova, Maria, Bönelt, Peter, Hoffmann, David, Koglgruber, Rubina, Steffen, Ulrike, Schett, Georg, Busslinger, Meinrad, Bergthaler, Andreas, Klein, Christoph, Penninger, Josef M.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953624/
https://ncbi.nlm.nih.gov/pubmed/32930709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200559
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