Jagunal-homolog 1 is a critical regulator of neutrophil function in fungal host defense

Neutrophils are key innate immune effector cells essential to fight bacterial and fungal pathogens. Here we report that mice carrying a hematopoietic lineage-specific deletion of Jagunal homolog 1 (Jagn1) cannot mount an efficient neutrophil-dependent immune response to the human fungal pathogen Can...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Wirnsberger, Gerald, Zwolanek, Florian, Stadlmann, Johannes, Tortola, Luigi, Liu, Shang Wan, Perlot, Thomas, Järvinen, Päivi, Dürnberger, Gerhard, Kozieradzki, Ivona, Sarao, Renu, De Martino, Alba, Boztug, Kaan, Mechtler, Karl, Kuchler, Karl, Klein, Christoph, Elling, Ulrich, Penninger, Josef M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245568/
https://ncbi.nlm.nih.gov/pubmed/25129145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3070
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