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Targeting mechanosensitive MDM4 promotes lung fibrosis resolution in aged mice

Aging is a strong risk factor and an independent prognostic factor for progressive human idiopathic pulmonary fibrosis (IPF). Aged mice develop nonresolving pulmonary fibrosis following lung injury. In this study, we found that mouse double minute 4 homolog (MDM4) is highly expressed in the fibrotic...

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Podrobná bibliografie
Vydáno v:J Exp Med
Hlavní autoři: Qu, Jing, Yang, Shan-Zhong, Zhu, Yi, Guo, Ting, Thannickal, Victor J., Zhou, Yong
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7953267/
https://ncbi.nlm.nih.gov/pubmed/33688918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20202033
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