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Targeting mechanosensitive MDM4 promotes lung fibrosis resolution in aged mice
Aging is a strong risk factor and an independent prognostic factor for progressive human idiopathic pulmonary fibrosis (IPF). Aged mice develop nonresolving pulmonary fibrosis following lung injury. In this study, we found that mouse double minute 4 homolog (MDM4) is highly expressed in the fibrotic...
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| Gepubliceerd in: | J Exp Med |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Rockefeller University Press
2021
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7953267/ https://ncbi.nlm.nih.gov/pubmed/33688918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20202033 |
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