Brd4-p300 inhibition downregulates Nox4 and accelerates lung fibrosis resolution in aged mice

Tissue regeneration capacity declines with aging in association with heightened oxidative stress. Expression of the oxidant-generating enzyme, NADPH oxidase 4 (Nox4), is elevated in aged mice with diminished capacity for fibrosis resolution. Bromodomain-containing protein 4 (Brd4) is a member of the...

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Publicat a:JCI Insight
Autors principals: Sanders, Yan Y., Lyv, Xing, Zhou, Q. Jennifer, Xiang, Zheyi, Stanford, Denise, Bodduluri, Sandeep, Rowe, Steven M., Thannickal, Victor J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7453889/
https://ncbi.nlm.nih.gov/pubmed/32544088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.137127
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