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Brd4-p300 inhibition downregulates Nox4 and accelerates lung fibrosis resolution in aged mice
Tissue regeneration capacity declines with aging in association with heightened oxidative stress. Expression of the oxidant-generating enzyme, NADPH oxidase 4 (Nox4), is elevated in aged mice with diminished capacity for fibrosis resolution. Bromodomain-containing protein 4 (Brd4) is a member of the...
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| Publicat a: | JCI Insight |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7453889/ https://ncbi.nlm.nih.gov/pubmed/32544088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.137127 |
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