Downregulation of NOX4 Expression by Roflumilast N-Oxide Reduces Markers of Fibrosis in Lung Fibroblasts

The phosphodiesterase 4 inhibitor roflumilast prevents bleomycin- (BLM-) induced lung fibrosis in animal models. However, its mechanism of action remains unknown. We investigated whether roflumilast N-oxide (RNO), the active metabolite of roflumilast, can modulate in vitro the oxidative effects of B...

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Detalhes bibliográficos
Main Authors: Vecchio, Daniela, Acquaviva, Alessandra, Arezzini, Beatrice, Tenor, Hermann, Martorana, Piero A., Gardi, Concetta
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763264/
https://ncbi.nlm.nih.gov/pubmed/24027357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/745984
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