Next generation of anti-PD-L1 Atezolizumab with enhanced anti-tumor efficacy in vivo

FDA-approved anti-PD-L1 antibody drug Atezolizumab is a human IgG1 without glycosylation by an N297A mutation. Aglycosylation of IgG1 has been used to completely remove the unwanted Fc-mediated functions such as antibody-dependent cytotoxicity (ADCC). However, aglycosylated Atezolizumab is unstable...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Li, Maohua, Zhao, Rongqing, Chen, Jianxin, Tian, Wenzhi, Xia, Chenxi, Liu, Xudong, Li, Yingzi, Li, Song, Sun, Hunter, Shen, Tong, Ren, Wenlin, Sun, Le
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7952408/
https://ncbi.nlm.nih.gov/pubmed/33707569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85329-9
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