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Next generation of anti-PD-L1 Atezolizumab with enhanced anti-tumor efficacy in vivo
FDA-approved anti-PD-L1 antibody drug Atezolizumab is a human IgG1 without glycosylation by an N297A mutation. Aglycosylation of IgG1 has been used to completely remove the unwanted Fc-mediated functions such as antibody-dependent cytotoxicity (ADCC). However, aglycosylated Atezolizumab is unstable...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7952408/ https://ncbi.nlm.nih.gov/pubmed/33707569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85329-9 |
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