Sunitinib Exerts In Vitro Immunomodulatory Activity on Sarcomas via Dendritic Cells and Synergizes With PD-1 Blockade

BACKGROUND: High-grade sarcomas are a heterogeneous group of aggressive tumors arising in bone and soft tissues. After relapse, treatment options are limited. The multi-targeted receptor tyrosine kinase inhibitors (TKIs) sunitinib and inhibitor of PD-1 (anti-PD-1) nivolumab have shown antitumor acti...

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Vydáno v:Front Immunol
Hlavní autoři: Ocadlikova, Darina, Lecciso, Mariangela, Broto, Javier Martin, Scotlandi, Katia, Cavo, Michele, Curti, Antonio, Palmerini, Emanuela
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7952316/
https://ncbi.nlm.nih.gov/pubmed/33717062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.577766
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