Phospho-valproic acid (MDC-1112) reduces pancreatic cancer growth in patient-derived tumor xenografts and KPC mice: enhanced efficacy when combined with gemcitabine

New chemotherapeutic agents are needed for pancreatic cancer (PC). We have previously shown that phospho-valproic acid (MDC-1112) is effective in cell-line xenografts of PC. Here, we explored whether MDC-1112 is effective in additional clinically relevant animal models of PC and whether MDC-1112 enh...

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Detalhes bibliográficos
Publicado no:Carcinogenesis
Main Authors: Luo, Dingyuan, Digiovanni, Matthew G, Wei, Ran, Lacomb, Joseph F, Williams, Jennie L, Rigas, Basil, Mackenzie, Gerardo G
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Carcinogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7951062/
https://ncbi.nlm.nih.gov/pubmed/31584613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgz170
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