The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer

The recent discovery of the cancer-associated E76K mutation in histone H2B (H2BE76-to-K) in several types of cancers revealed a new class of oncohistone. H2BE76K weakens the stability of histone octamers, alters gene expression, and promotes colony formation. However, the mechanism linking the H2BE7...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kang, Tze Zhen Evangeline, Zhu, Lina, Yang, Du, Ding, Dongbo, Zhu, Xiaoxuan, Wan, Yi Ching Esther, Liu, Jiaxian, Ramakrishnan, Saravanan, Chan, Landon Long, Chan, Siu Yuen, Wang, Xin, Gan, Haiyun, Han, Junhong, Ishibashi, Toyotaka, Li, Qing, Chan, Kui Ming
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949156/
https://ncbi.nlm.nih.gov/pubmed/33548228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100374
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados