The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer

The recent discovery of the cancer-associated E76K mutation in histone H2B (H2BE76-to-K) in several types of cancers revealed a new class of oncohistone. H2BE76K weakens the stability of histone octamers, alters gene expression, and promotes colony formation. However, the mechanism linking the H2BE7...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Biol Chem
Κύριοι συγγραφείς: Kang, Tze Zhen Evangeline, Zhu, Lina, Yang, Du, Ding, Dongbo, Zhu, Xiaoxuan, Wan, Yi Ching Esther, Liu, Jiaxian, Ramakrishnan, Saravanan, Chan, Landon Long, Chan, Siu Yuen, Wang, Xin, Gan, Haiyun, Han, Junhong, Ishibashi, Toyotaka, Li, Qing, Chan, Kui Ming
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2021
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949156/
https://ncbi.nlm.nih.gov/pubmed/33548228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100374
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