Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells

ST6Gal-I, an enzyme upregulated in numerous malignancies, adds α2-6-linked sialic acids to select membrane receptors, thereby modulating receptor signaling and cell phenotype. In this study, we investigated ST6Gal-I’s role in epithelial to mesenchymal transition (EMT) using the Suit2 pancreatic canc...

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Vydáno v:J Biol Chem
Hlavní autoři: Britain, Colleen M., Bhalerao, Nikita, Silva, Austin D., Chakraborty, Asmi, Buchsbaum, Donald J., Crowley, Michael R., Crossman, David K., Edwards, Yvonne J.K., Bellis, Susan L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949065/
https://ncbi.nlm.nih.gov/pubmed/33148698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014126
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