Biophysical characterization of the ETV6 PNT domain polymerization interfaces

ETV6 is an E26 transformation specific family transcriptional repressor that self-associates by its PNT domain to facilitate cooperative DNA binding. Chromosomal translocations frequently generate constitutively active oncoproteins with the ETV6 PNT domain fused to the kinase domain of one of many p...

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Udgivet i:J Biol Chem
Main Authors: Gerak, Chloe A.N., Cho, Sophia Y., Kolesnikov, Maxim, Okon, Mark, Murphy, Michael E.P., Sessions, Richard B., Roberge, Michel, McIntosh, Lawrence P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2021
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949025/
https://ncbi.nlm.nih.gov/pubmed/33450226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100284
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